They became an iconic trio when they starred on Friends for almost a decade.
Now, Courtney Cox, Jennifer Aniston and Lisa Kudrow have delighted fans of the hit sitcom, which aired from 1994 to 2004, by reuniting for a smiling snap.
The occasion was to celebrate the 55th birthday of the Monica Geller actress.
She shared a selfie of herself with 50-year-old Jennifer, who played Rachel Green, and Lisa, who played Phoebe Buffay, to Instagram.
Captioning the sweet image, Courteney - who has a 15-year-old daughter Coco with ex-husband David Arquette - wrote: “How lucky am I to celebrate my birthday with these two??? I love you girls. So much.”
Lisa, 55, was quick to reply: “LOVE you girls! Happy happy Court.”
Selma Blair and Poppy Delevingne were among other celebrities to wish the Cougar Town star a happy birthday.
Her 2.3m followers were delighted by the impromptu reunion of the show’s three female leads.
The snap has been ‘liked’ 896k times, and fans revealed their amazement at how little the women had aged.
One person wrote: “My heart just exploded.”
Another commented: “After all these years they're still good friends.”
A third shared: “Aww they are still Besties.”
In another post, Courteney paid tribute to her boyfriend Johnny McDaid.
Captioning a pic of the couple, she wrote: “My all year birthday gift! I miss you J xx”
The Snow Patrol guitarist - with whom she broke off her engagement in 2015 before reuniting - is based in London.
Many fans said they hoped a show reunion is on the cards.
Last month marked 15 years since the final episode of the show first aired.