United have been far from their best this season. They required their latest ever Premier League comeback to beat Brentford before an international break they returned from with a win by the same scoreline at rock-bottom Sheffield United.
Erik ten Hag's team toiled to a third straight victory in all competitions on Tuesday, when Andre Onana's last-gasp spot-kick save sealed a crucial 1-0 win against Copenhagen in the Champions League. It was another narrow escape for a United side that need to be far better if they are to stand any chance of winning the 191st Manchester derby.
City have also not been at their best but still find themselves firmly in the top four, six points ahead of their neighbours in eighth. Last season's treble winners lost two consecutive Premier League games before the international break but bounced back with wins over Brighton and Young Boys.
The champions crushed United 6-3 at home last season, but lost 2-1 at Old Trafford. City also beat United in the FA Cup final this year and went on to matching United's achievement of the treble in 1999.
Where to watch Man United vs Man City
TV channel: In the UK, the game will be televised live on Sky Sports, with coverage beginning at 3pm GMT ahead of kick-off at 3.30pm.
Live stream: Subscribers can also catch the contest live online via the Sky Sports app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.