The England striker was criticised by under-fire manager Erik ten Hag for an "unacceptable" birthday party that was held in a nightclub after last weekend's dire home derby defeat by Manchester City.
Rashford isn't in the squad at all for this afternoon's trip to Craven Cottage, with United confirming that he pulled up with an issue that took him out of training on Friday and subsequently failed a late fitness test.
Casemiro is also out for several weeks again after suffering a hamstring injury on his short-lived return from an ankle problem in the miserable Carabao Cup defeat by Newcastle in midweek.
The fit-again Raphael Varane is only on the bench once again, with Victor Lindelof missing due to illness and Harry Maguire lining up alongside Jonny Evans in central defence.
Aaron Wan-Bissaka makes his first start since early September after hamstring trouble to refresh a backline in desperate need of some defensive nous.
With no Rashford, Rasmus Hojlund is supported by Antony and Alejandro Garnacho in attack, with captain Bruno Fernandes also back in the starting XI.
Scott McTominay and Christian Eriksen return to midfield, with Diogo Dalot and Andre Onana also retaining their starting berths.
Mason Mount and Sofyan Amrabat are both on the bench, along with the likes of Anthony Martial, Sergio Reguilon and youngsters Kobbie Mainoo and Hannibal Mejbri.
Manchester United XI: Onana, Wan-Bissaka, Maguire, Evans, Dalot, Eriksen, McTominay, Antony, Bruno Fernandes, Garnacho, Hojlund
Subs: Bayindir, Amrabat, Mount, Martial, Reguilon, Varane, Pellistri, Mainoo, Mejbri
Injured: Rashford, Martinez, Malacia, Shaw, Amad, Casemiro
Time and date: 12:30pm GMT, Saturday November 4, 2023
Venue: Craven Cottage