Gabriel Jesus is absent after injuring his hamstring on Tuesday in the Champions League when the Gunners beat Sevilla. He underwent a scan on Thursday and will now miss the coming "few weeks" along with Thomas Partey.
Eddie Nketiah comes in for Jesus with Mikel Arteta also bringing in Jakub Kiwior and Kai Havertz for the rested first-teamers.
Takehiro Tomiyasu drops out, even after he shone in Sevilla on Tuesday, and Emile Smith Rowe gets the nod over Jorginho.
Arsenal should have plenty of the ball on Saturday at Emirates Stadium and, as such, Oleksandr Zinchenko comes in at left-back.
Arsenal XI: Raya; White, Saliba, Kiwior, Zinchenko; Smith Rowe, Rice, Havertz; Saka, Nketiah, Martinelli
Subs: Ramsdale, Tomiyasu, Gabriel, Jorginho, Elneny, Vieira, Odegaard, Nelson, Trossard
Injuries: Timber, Jesus, Partey
Date and time: 3pm, Saturday October 28, 2023
Venue: Emirates Stadium